how does diabetes increase the risk of sepsis from blood infection?

 Diabetes can increase the risk of sepsis from bacteremia in several ways, as follows:

• Functional immune deficiency: Diabetes can cause a functional immune deficiency that directly reduces immune cell function, leading to diminished bactericidal clearance, increased infectious complications, and protracted sepsis mortality
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• Chronic inflammation: Diabetes is associated with chronic inflammation, which can lead to immune suppression and affect an individual's overall immune system homeostasis
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• Impaired immune response: Uncontrolled hyperglycemia is associated with impaired innate and adaptive immune responses that predispose to bacterial infections
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• Increased susceptibility to infections: People with diabetes are at higher risk of developing wounds and sores that don’t heal well. While the wounds are present, they are at high risk of developing an infection, which can lead to sepsis
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• Poor glycemic control: Poor glycemic control can lead to a higher risk of infections, which can increase the risk of developing sepsis from bacteremia
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• Increased mortality: Diabetic mortality from sepsis is predicted to rise dramatically over the next two decades
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It is important to note that the risk factors for developing sepsis from bacteremia may vary from person to person, and the severity of sepsis may depend on the underlying health condition

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frontiersin

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nih

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nih

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sepsis

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healthline