According to a new study conducted in Scotland and the Netherlands, the response of our immune system to a vaccine also depends on how we were born, i.e. through normal delivery or operation (C-section).
The study found that children born in normal delivery or naturally born have twice the amount of antibodies produced after vaccination compared to children born through surgery (C-section).
Experts say that the reason for this difference is the good immunity-producing bacteria that accumulate in our body at birth. Although children born after the operation also have immunity or natural protection, they may have to be given more probiotic or additional doses of the vaccine than children born with normal delivery.
The moment of our birth is a time when we move out of the germs of the mother’s uterus to a world where there are a lot of microscopic germs everywhere. The microbes (bacteria, fungi, viruses, and ikea) in this microscopic life make our body their home and eventually outnumber our ‘human’ cells.
If we come into this world without a natural method i.e. operation, then the microbes from which we are first brought up are present in our mother’s vagina, but if you are born through operation or C-section, then your way to this world becomes different and the germs that fall on your forehead are found on human skin. or in the air of the hospital and home.
In the current study, experts from the University of Edinburgh and The University of Utrecht in the Netherlands were examining the effects of these microbes on the different vaccines given to us after our birth. For this purpose, experts studied the stools of 120 newborns from the first dark green stool (meconium) to the age of one year.
The findings, published in the Journal of Nature Communication, showed that babies born vaginally had higher amounts of microbes of the Bifidobacterium and Eskerichia coli breed.
In light of these results, experts say that the high amount of these useful bacteria means that when such children are given pneumococcal and menigococcal types of vaccines, the amount of antibodies that cause immunity against the disease will almost double. It has been seen before that the microbes in our body affect the flu and tuberculosis (TB) vaccine.
Professor Debbie Bogart, head of the Department of Pediatrics at the University of Edinburgh, said, "The first link between microbes and our immune system at birth is important. He said that bacteria release a variety of chemical components, called fatty acids. These fatty acids tell our immune system to start working now.
If these fatty acids are not there, then the growth of B cells type cells in the body is weakened and these are the cells that produce white cells in our body that fight against disease. The newborns studied in this study were all healthy, were born at the end of the term and did not suffer from any other disease.
What can be done in this regard?
Often the operation or C-section is done when the purpose is to protect the health of the mother or child. In recent times, there has also been a trend of ‘vaginal seeding’ in which a natural liquid released from the mother is applied to the body of the child born from the operation. Apart from this, another study even did that the bacteria found in the mother’s stomach were inserted into the child’s body.
The main purpose of all these experiments was to get the microbes that the child could not get due to the C-section. However, Professor Bogart says, "Giving microbes to children with C-sections may be the best solution, but in practice it is a very complex process because it can be dangerous for the child." That’s why Professor Bogart says it would be "safer" to give children born with C-sections a mixture of useful bacteria (such as probiotics). Another solution is to give additional doses of the vaccine to children with C-sections. ‘
On the other hand, according to Professor Neil Mabot, an immune system expert and associated with the University of Edinburgh, it cannot be said with certainty that the production of more antibodies in a child is directly related to microbes. However, he said, "Recent research has nevertheless raised the possibility that we can provide useful bacteria to improve the immune system of newborns, especially those born after the operation, improve the effects of the vaccine, and protect these children from other infections." ‘
Commenting on the study, bioscience expert Dr. George Swa said, "This article is important in that it will help us more to understand the factors that affect vaccines and microbiomes in newborns. However, he said that this research has been done on a relatively limited scale and we need more research before any final conclusions can be drawn.
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