Alpha-1 antitrypsin deficiency is typically inherited in an autosomal co-dominant pattern. This means that an affected individual inherits one defective alpha-1 antitrypsin gene (allele) from each parent. Each parent may be a carrier of the defective gene or have the condition themselves. Offspring of two carrier individuals have a 25% chance of inheriting two defective genes and developing the condition, a 50% chance of being carriers themselves, and a 25% chance of inheriting two normal genes. It’s important for individuals with a family history of alpha-1 antitrypsin deficiency to consult with a healthcare professional or a genetic counselor for a more personalized assessment.
Learn more : Inheritance of Alpha-1 Antitrypsin Deficiency
