Tag: semaglutide

Glucose-regulating medications used to treat type 2 diabetes have also been shown to have very positive effects on obesity

Glucose-regulating medications used to treat type 2 diabetes have also been shown to have very positive effects on obesity, which may alter how obesity is treated.

Anti-diabetic drugs with glucose-regulating effects have been shown to have a significant weight-reducing effect in obese patients, with tirzepatid providing a weight reduction of more than 20%, comparable to bariatric surgery.

Semaglutide had the same good effect in a study among teenagers 4 , and a similar study is underway regarding tirzepatid.

Semaglutide and tirzepatide are peptides in the incretin class that mimic intestinal hormones and stimulate insulin secretion. Semaglutide works by activating the GLP-1 receptor, while tirzepatid works by activating both the GLP-1 and GIP receptors. Clinical effects include increased satiety, delayed gastric emptying, increased insulin and insulin sensitivity, decreased glucagon, and lower blood glucose levels. Side effects include nausea, vomiting, abdominal pain, constipation, and diarrhea.

In a direct comparative randomized trial, tirzepatid outperformed semaglutide 7 in terms of glucose control. Both drugs had highly beneficial effects on lipids, resulting in lower triglycerides, lower LDL cholesterol, and higher HDL cholesterol, as well as lower blood pressure.

These drugs are very expensive and must be taken for 12–18 months before the full effect occurs. And if the patient is unable to change their lifestyle, it is likely that the weight will increase again when the drug treatment stops.


The global obesity epidemic has worsened, with 650 million obese adults and 340 million between the ages of 5 and 18. New drugs represent a breakthrough, providing weight reduction, cardiovascular risk factors, glucose regulation, reverse fatty liver, and reducing the effects obesity has on osteoarthritis and cancer.

The downsides are the price, the side effects, the fact that the drugs have to be given as injections, and the risk of relapse as soon as the treatment is over. 

Semaglutide is also available as a tablet, but this form is much less effective at helping people lose weight. But this means that in the future, it might be possible to make oral drugs that have the same effects. Several similar new drugs are in the works, which could lead to more competition and lower, more reasonable prices.

How much weight can I lose using semaglutide ?

You can lose up to 15% of your starting body weight when using semaglutide in injections for weight loss (such as Ozempic). From 0.25 mg at the beginning to 2.4 mg once a week by week 16, the semaglutide dosage is gradually increased. In order to answer the question “how much weight can you lose with semaglutide,” researchers at the University of Liverpool created a study with very specific guidelines.

A group of 1961 adults was gathered who had a BMI that indicated obesity (>30). The average weight loss in those who received the semaglutide slimming injection was nearly 15% (as opposed to the placebo’s -2.4%). You can shed about 15 kg in 68 weeks by taking Ozempic or another medication along with semaglutide once per week (17 months).

Here are the precise weight loss results and advancements made by a group of almost 2,000 participants in a study released in 2021. Two research subgroups were created from the participant pool.


The first received a weekly slimming injection with semaglutide (the same substance found in, for example, Ozempic) starting at a dose of 0.25 mg to 2.4 mg, and received recommendations on how to lose weight through lifestyle changes.

  1. The first received a weekly slimming injection with semaglutide (the same substance found in, for example, Ozempic) starting at a dose of 0.25 mg to 2.4 mg, and received recommendations on how to lose weight through lifestyle changes.
  2. The second group of people received only recommendations regarding lifestyle changes for effective weight loss.

Weight loss with semaglutide slimming injections (e.g. Ozempic) progressed as follows:

  • 1st month (4 weeks) of slimming injections – approx. -2.5% of the initial body weight (a person weighing 100 kg loses 2.5 kg);
  • 2nd month (8 weeks) of slimming injections – approx. -4% of the initial body weight (a person weighing 100 kg loses approx. 4 kg);
  • 3rd month (12 weeks) of slimming injections – approx. -6% of the initial body weight (a person weighing 100 kg loses approx. 6 kg);
  • 4th month (16 weeks) of slimming injections – approx. -8% of the initial body weight (a person weighing 100 kg loses approx. 8 kg);
  • 5th month (20 weeks) of slimming injections – approx. -9.5% of the initial body weight (a person weighing 100 kg loses approx. 9.5 kg);

After the fifth month of taking slimming injections, you can still lose weight effectively, but the pace of weight loss is noticeably slowing down:

  • 7th month (28 weeks) of slimming injections – approx. -11.5% of the initial body weight (a person weighing 100 kg loses approx. 11.5 kg);
  • 9th month (36 weeks) of slimming injections – approx. -13% of the initial body weight (a person weighing 100 kg loses approx. 13 kg);
  • 11th month (44 weeks) of slimming injections – approx. -14.8% of the initial body weight (a person weighing 100 kg loses approx. 14.8 kg);
  • 13th month (52 weeks) of slimming injections – approx. -15.8% of the initial body weight (a person weighing 100 kg loses approx. 15.8 kg);
  • 15th month (60 weeks) of slimming injections – approx. 14.9% of the initial body weight (a person weighing 100 kg loses approx. 14.9 kg).

But more than just the average weight loss is remarkable. Even more amazing is the difference in the number of people who benefited from slimming injections versus those who benefited from dietary advice alone. When taking semaglutide injections once a week, as many as 86.4% of participants actually lost weight, as opposed to 31.5% of participants who lost weight only after being given advice (without injections). The following table displays the precise data:

Weight Loss/InterventionWeight loss injection once a week – semaglutide (e.g. Ozempic)Nutrition education and lifestyle change (placebo)
Weight loss of 5% or more compared to your starting weight86.4% of people joining the study (1047 people from the study)31.5% of people joining the study (182 people)
Weight loss of 10% or more compared to your starting weight69.1% of people joining the study (838 people from the study)12% of people joining the study (69)
Weight loss of 15% or more compared to your starting weight50.5% (612 people from the study)4.9% of people joining the study (28)

The table clearly shows that injecting semaglutide resulted in much more effective weight loss than just changing eating habits.

Works Cited

“Zastrzyki Na Odchudzanie – Ile Można Schudnąć? – Polki.pl.” Polki.pl, 24 Jan. 2023, polki.pl/dieta-i-fitness/odchudzanie,zastrzyki-na-odchudzanie-ile-mozna-schudnac-spodziewane-efekty,10448926,artykul.html.

Don’t combine popular weight loss injections with other drugs

This case demonstrates how dangerous it can be to combine popular “weight loss injections” with other drugs. A young woman who was prescribed weight-loss medication nearly died as a result of dangerous complications. Doctors warn that taking too many drugs can result in dangerous organ damage.

A patient was prescribed  semaglutide, one of the most recently popular prescription drugs for weight loss. When combined with other drugs, the therapy proved to be a lethal threat. Doctors refer to this phenomenon as polypragmasia, which refers to multi-drug therapy, the side effects of which frequently outweigh the therapeutic effect.

Therapy with “injections for slimming” led almost to a tragedy

There were media reports about a 29-year-old patient at an obesity treatment clinic who experienced dangerous side effects from the therapy. The woman was given the popular injectable semaglutide as well as the antidepressant and antiemetic combination drug bupropion+naltrexone, which is used to treat obesity. Her weight was dropping, but not due to the therapeutic effect of the prescribed medications, but due to the debilitating effect of the incorrect treatment on the body.

The patient developed infection-like symptoms (fever, sweats, chills) after 14 days of treatment that did not improve with antipyretics. She was then admitted to the intensive care unit due to potentially fatal complications. Renal failure and serotonin syndrome were diagnosed by doctors. Fortunately, it was discovered that the woman’s medications caused dangerous interactions and side effects. The patient’s life was saved. However, the story could have ended differently.

Beware of drug combinations with ‘weight loss injections

Semaglutide and other drugs in the GLP-1 analogue class, also known as slimming injections, have recently gained popularity due to their weight-loss properties. They can, however, interfere with drug absorption. Semaglutide slows stomach emptying, affecting the rate at which other substances are absorbed. As a result, people who take medications should exercise caution and keep in mind that they may experience side effects. Although it should be noted that the 29-year-old patient’s dangerous condition was caused by the interaction of other drugs as well.

Polypharmacy is becoming an increasingly common problem, according to experts. It usually involves elderly people who are often afflicted with multiple diseases and to whom doctors from various specialties prescribe drugs without comprehensive treatment coordination. Excessive use is caused by the patient’s lack of knowledge about the other pharmacological agents he or she is taking. As a result, therapy may be more harmful than beneficial. As a result, raising patient awareness of the issue is critical. It’s always a good idea to tell your doctor about any medications you’re taking (even if he doesn’t ask) and to report any troubling symptoms as soon as possible.

“Młoda Kobieta Przyjmowała Zastrzyki Na Odchudzanie. Omal Nie Przypłaciła Leczenia Życiem – Polki.pl.” Polki.pl, 3 Mar. 2023, stylzycia.polki.pl/leki,mloda-kobieta-brala-popularne-zastrzyki-na-odchudzanie-prawie-zmarla,10449736,artykul.html.

Use of semaglutide for weight loss : Which signs need to be taken seriously?

Are you using semaglutide or other “weight loss injections”? You need to be aware of the signs that point to pancreatic issues. Many people are unaware of the potential side effects of semaglutide and comparable medications, including pancreatitis.

see also : Slimming injections : Do they work?

semaglutide for pancreatitis and weight loss. Observe your symptoms

Semaglutide and other GLP-1 analogs reduce body weight, but can have harmful effects on the pancreas.

Semaglutide is an incretin drug that makes the body make more insulin and lowers blood sugar levels. This makes it a good choice for people with type 2 diabetes. It also reduces body weight and protects the circulatory system.

How does semaglutide work on the pancreas?

Semaglutide and other GLP-1 analogues turn on GLP-1 receptors in beta cells and exocrine ducts of the pancreas. This can cause the cells to grow too fast, block the ducts, and cause pancreatitis. But fewer than 1 in 100 people who take the drug get inflammation of the pancreas, and those people are more likely to get dangerous pancreatic cancer. 

Semaglutide and the pancreas. What symptoms should be of concern?


Acute pancreatitis is marked by severe stomach pain, vomiting, fever, tightness in the stomach, and a fast heart rate. Chronic pancreatitis is marked by pain in the abdomen, vomiting, and diarrhoea that gets worse after eating fatty foods. Semaglutide can also interact with other drugs, leading to dangerous interactions. A woman almost died after taking injections for slimming.