Tag: weight loss

How does oral Semaglutide differ from an injectable weight loss drug?

Semaglutide is one of the most sought-after drugs in the world today. It aids in the fight against obesity and diabetes. It is available for purchase as injections (Ozempic) or tablets (Rybelsus). However, the injectable drug is more popular than the oral drug. Are they extremely dissimilar to one another?

Semaglutide is a medication for type 2 diabetes, but due to its significant impact on weight loss, it has become one of the most sought-after drugs worldwide, and not just among diabetics (more: dangerous trend with diabetes injections). available on prescription only. Although the official indications for semaglutide include the treatment of diabetes, it is known that the drug is also prescribed off-label to obese patients. Due to the high demand, pharmacies continue to lack it.

a popular weight loss drug

Two medicines containing the active substance semaglutide are available on the market:

  • Ozempic—given as an injection once a week,
  • Rybelsus – administered in the form of a tablet orally daily.

Even though the active ingredient in both medicines is the same, Ozempic is more popular, and it is mostly this medicine that is not available in pharmacies. Are semglutide tablets less effective? The similarities and differences between the two drugs were examined.

How does semaglutide work?

Ozempic and Rybelsus’ active ingredient, semgalutide, is used to treat diabetes and obesity. It works by mimicking the incretin hormone glucagon-like peptide 1 (GLP-1), which the intestines secrete after a meal. Consequently, there is a rise in insulin secretion, which regulates glucose levels. Importantly, these drugs only increase insulin levels when glucose levels are elevated, making their use associated with a low risk of hypoglycemia (i.e., an excessive and dangerous drop in sugar). Consequently, these medications are safe for diabetic patients.

Benefits of using semaglutide:

  • lowers blood glucose levels,
  • lowers body weight (more:  slimming injections: how much can you lose? ),
  • reduces appetite, 
  • has a cardioprotective effect, which means it protects against atherosclerosis and lowers the risk of dying from heart disease or stroke.
  • slows down the progression of chronic kidney disease.

The drug can be taken alone or with other anti-diabetes medicines.

Oral semaglutide vs. injection: main differences

Oral Rybelsus semaglutide is the first and only GLP-1 analogue available orally. It functions similarly to an injectable medication and has a cardiovascular safety profile that is comparable. In comparison to Ozempic, its primary disadvantage is that it must be taken daily, as opposed to weekly injections.

Tablets may have a slower rate of drug absorption than injections, which could mean that they have less of a therapeutic effect. Less bioavailability of the tablets may cause less weight loss than expected or less control over blood sugar levels. However, following the directions for semaglutide administration may prevent poor absorption:

  • The tablet must be taken on an empty stomach , swallowed whole, and washed down with a small amount of water,
  • then wait at least 30 minutes before eating or drinking anything.

It’s important to remember that how well semaglutide works, whether it’s taken by mouth or injected, depends on how you live. Therapy should include a proper diet and regular physical activity

Oral semaglutide – side effects

Tablets may have a slower rate of drug absorption than injections, which could mean that they have less of a therapeutic effect. Less bioavailability of the tablets may cause less weight loss than expected or less control over blood sugar levels. However, following the directions for semaglutide administration may prevent poor absorption:

  • progression of retinopathy (in people who already have changes in the fundus of the eye),
  • inflammation of the pancreas,
  • heartburn,
  • constipation,
  • tiredness,
  • loss of appetite or taste disturbances
  • allergy,
  • cholelithiasis,
  • tachycardia. 

It should also be remembered that although the drug is unlikely to pose a risk of hypoglycemia, the risk of hypoglycaemia is higher in people who are taking a drug containing a sulfonylurea or insulin at the same time. Therefore, in these cases, low sugar is a potential side effect. 

See also : Slimming injections : Do they work?

Limited diet may be more effective for weight loss than starvation

A study published in the Journal of the American Heart Association in Dallas, January 20, 2023, suggests that low calorie consumption may be more effective for weight loss than starvation.

Three major health systems (Johns Hopkins Health System, Niger Health System and University of Pittsburgh Medical Center) studied 547 men and women for six months on weight trends, normal diet, and sleep/meal duration.

These weight trends were compared with weight and height recorded during past clinic visits (up to 10 years before being part of the research).

Food intake was divided into three groups: the first group was high (more than 1000 calories), the second group was medium (between 500 and 1000 calories) and the third group was low (less than 500 calories).

The study found that the average number of high and medium foods was the cause of weight gain, which concluded that overall consumption of calories is an important cause of weight gain. On the contrary, the number of foods in small amounts was the reason for weight loss over time.

According to the research, the interval between the first and last meals was not related to weight change. For the participants in the study, this interval was an average of 11 hours.

For the purposes of this research, the researchers described starvation as a routine of eating in limited times. Doing so helped the researchers compare weight trends between sleep and meal times.

Dr. D. Zhao, the lead author of the study, said that this research does not support the long-term strategy of weight loss as a factor, but excessive food loss can be more effective in weight loss, but clinical trials are needed to confirm the results of the research.

Obesity can be prevented by adopting four simple habits

Obesity is the root cause of hundreds of ailments, and it is now a global epidemic. However, you can avoid this disease with dietary changes, exercise, and vigilance. In this regard, the World Health Organization (WHO), a United Nations subsidiary, has issued some very basic suggestions that we might follow to avoid obesity and numerous ailments.

The most important thing is to move regularly and to avoid sitting for extended periods of time. Other significant measures, however, include these.

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Eat cabbage if you want to lose weight

Cabbage contains vitamin A, vitamin C, iron, fiber, zinc, phosphorus, magnesium, calcium, and other important nutritional benefits

see also : Cabbage soup for slimming – cheap, tasty and filling, and the portion has only 100 kcal

cabbage for slimming
Photo by Chokniti Khongchum on Pexels.com

In the modern era, where it is difficult to catch the running thorns of the clock, it seems impossible to take care of your health and especially weight, but there is a vegetable used in your kitchen that helps in losing weight.

Of course, cabbage is used in every household and today we will tell you how to lose weight from cabbage as well as its usefulness.

Nutritional benefits of cabbage:

Cabbage contains vitamin A, vitamin C, iron, fiber, zinc, phosphorus, magnesium, calcium, and other important nutritional benefits, it also contains antioxidants that help protect against diseases like cancer, while cabbage helps in improving digestive system, controlling blood pressure and lowering cholesterol in the body.

In terms of calories, according to a study, 100 grams of cabbage contains 25 calories, which helps in losing weight.

Use of cabbage:

Cabbage can be used in different ways, to lose weight, you can mix cabbage with other vegetables and eat it in the form of salad, while many people also use cabbage by adding it to soup or rawot.

WHO has given simple guidelines for good health and obesity, which are also very easy to follow

Numerous diseases, including those that induce obesity, are now considered a global issue. However, you can prevent this condition with sensible dietary choices, regular exercise, and vigilance. In this regard, the World Health Organization (WHO), a division of the United Nations, has provided some extremely fundamental recommendations that we can follow to prevent obesity and a number of ailments.

Obesity can be prevented by adopting four simple habits

The most crucial thing is to routinely exercise and refrain from spending too much time sitting still. These are some more crucial criteria though.

Avoid salt and sugar.

The dreadful sickness of our day, sugar intake, is now exacting its vengeance on us in the form of diabetes. Experts from throughout the world concur that lowering sugar has numerous immediate advantages and lowers obesity. Sugar consumption without restriction leads to diabetes, which in turn contributes directly or indirectly to rising cholesterol, blood pressure, and heart disease.

The minimal use of salt is the second crucial factor. Fast food, chips, pizza, etc. are particularly salty in today’s fast-paced world. The World Health Organization recommends that adults consume no more than five grammes of salt per day. Salt causes us to gain weight and may cause blood pressure problems even before that.

Because of this, it’s crucial to stay away from salt and sugar.

Fatty food

Greasy, oily foods are detrimental to our health. While they are raising cholesterol, they are also raising many other problems, including high pressure. It is crucial to fully avoid oily foods because of this. Our weight continues to increase as a result of the progressive accumulation of fat in our bodies.

Balanced meals

Although there is much discussion surrounding balanced diets, experts agree that a diet that includes all the vitamins, proteins, and other vital elements constitutes a balanced diet. Fruits, vegetables, meat, eggs, legumes, and other products fall under this category. This is the reason that a balanced diet also keeps bodily processes in check, preventing obesity.

Liquor

The importance of drinking after eating cannot be overstated. Avoiding sugar-filled beverages, soft drinks, and energy drinks at any costs is a smart practise. According to some study, the primary contributors to obesity are soda and other sweet drinks. But as we’ve already mentioned, these drinks are loaded with sugar.